[细胞周期蛋白D1、E和A在人类乳腺疾病中的差异表达]
[Differential expression of cyclins D1, E and A in human breast diseases].
作者信息
Ma L, Yin H, Yang W, Yang G, Lü Q, Liu X
机构信息
Laboratory Animal Center, WCUMS, Chengdu 610041, China.
出版信息
Hua Xi Yi Ke Da Xue Xue Bao. 2001 Dec;32(4):497-500.
OBJECTIVE
To understand with greater clearness the effect of overexpression of cyclins gene and the potential implications of it for tumorgenesis in breast.
METHODS
We assayed the expression of cyclins D1, E and A in different types of human breast diseases by immunohistochemical staining.
RESULTS
Significant difference was seen among the malignant tumor, benign tumor and dysplasis(P < 0.001). The expressive intensity of above three kind of cyclins in malignant tumor was the highest, that in benign tumor was higher, and that in dysplasis was low.
CONCLUSION
These data suggest that the expressive intensity of cyclins gene may serve as an indicator for malignant intensity of tumors. The expressive ratio difference of cyclins E and A between infiltrating ductal carcinoma and infiltrating lobular carcinoma may imply that there are different mechanisms involving the occurrence of different histological types of breast tumor.
目的
更清晰地了解细胞周期蛋白基因过表达的影响及其对乳腺癌发生的潜在意义。
方法
通过免疫组织化学染色检测细胞周期蛋白D1、E和A在不同类型人类乳腺疾病中的表达。
结果
恶性肿瘤、良性肿瘤和发育异常之间存在显著差异（P < 0.001）。上述三种细胞周期蛋白在恶性肿瘤中的表达强度最高，在良性肿瘤中较高，在发育异常中较低。
结论
这些数据表明，细胞周期蛋白基因的表达强度可能作为肿瘤恶性程度的指标。浸润性导管癌和浸润性小叶癌之间细胞周期蛋白E和A的表达率差异可能意味着不同组织学类型乳腺肿瘤的发生涉及不同机制。
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