Tsukamoto Y, Taira E, Kajimura K, Yamate J, Kotani T, Amin H, Kohama K, Sakuma S, Miki N, Sasaki F
Department of Veterinary Anatomy, Department of Veterinary Pathology, College of Agriculture, Osaka Prefecture University, 1-1 Gakuencho, Sakai, Osaka, 599-8531, Japan.
Exp Cell Res. 1999 Mar 15;247(2):329-38. doi: 10.1006/excr.1998.4367.
Gicerin is a novel cell adhesion molecule in the immunoglobulin superfamily and has both homophilic adhesion and heterophilic adhesive activity to neurite outgrowth factor (NOF), an extracellular matrix protein in the laminin family. We investigated the possible involvement of gicerin in oviductal development, regeneration, and metastasis of oviductal adenocarcinomas of the chicken. In the oviductal epithelium, gicerin was expressed strongly during development, disappeared after maturation, and reappeared during regeneration. NOF was constitutively expressed in the basement membrane of the epithelium. These molecules were expressed strongly in oviductal adenocarcinomas in both primary and metastatic lesions in the mesentery. An anti-gicerin antibody inhibited the attachment of adenocarcinoma cells to the mesentery in vitro. Many cells migrated from adenocarcinoma tissues on NOF, which were inhibited by an anti-gicerin antibody. These results suggest that gicerin might play a role in oviductal development and regeneration and also in the metastasis of adenocarcinomas.
Gicerin是免疫球蛋白超家族中的一种新型细胞粘附分子，对神经突生长因子（NOF，层粘连蛋白家族中的一种细胞外基质蛋白）具有同源性粘附和异源性粘附活性。我们研究了gicerin在鸡输卵管发育、再生以及输卵管腺癌转移过程中可能发挥的作用。在输卵管上皮中，gicerin在发育过程中强烈表达，成熟后消失，并在再生过程中再次出现。NOF在上皮基底膜中持续表达。这些分子在原发性和肠系膜转移性输卵管腺癌中均强烈表达。抗gicerin抗体在体外可抑制腺癌细胞与肠系膜的附着。许多细胞从腺癌组织迁移到NOF上，而这一过程受到抗gicerin抗体的抑制。这些结果表明，gicerin可能在输卵管发育和再生以及腺癌转移中发挥作用。
