Department of Animal Hygiene, Graduate School of Biology and Environmental Sciences, Kyoto Prefecture University, Kyoto 606-8522, Japan.
Int J Mol Med. 2010 Nov;26(5):661-6. doi: 10.3892/ijmm_00000511.
Gicerin is a cell adhesion molecule in the immunoglobulin superfamily. This molecule has homophilic and heterophilic adhesive activities, binding to the neurite out-growth factor (NOF). We have previously reported that gicerin plays an important role in the development and regeneration as well as in the metastasis of tumors through its adhesive activities, mediating cell-cell and/or cell-extracellular matrix interactions. In this study, we investigated the involvement of gicerin in a dermal autograft chicken model. Gicerin and NOF were transiently present in the regenerating epithelia after the dermal graft transplantation. The treatment with an anti-gicerin polyclonal antibody, by placing drops onto the wounds, inhibited the adhesiveness of the grafts to the marginal skin. The chimeric protein of gicerin-IgG, gicerin-Fc, and NOF proteins promoted the regeneration of the grafts. These findings suggest the potential function of gicerin in dermal autografts, and gicerin and NOF proteins could help clinical improvement after transplantations.
Gicerin 是免疫球蛋白超家族中的一种细胞粘附分子。该分子具有同亲性和异亲性粘附活性，与神经突生长因子 (NOF) 结合。我们之前的研究报告表明，gicerin 通过其粘附活性在肿瘤的发育和再生以及转移中发挥重要作用，介导细胞-细胞和/或细胞-细胞外基质相互作用。在这项研究中，我们研究了 gicerin 在皮肤自体移植物鸡模型中的作用。在皮肤移植物移植后，gicerin 和 NOF 短暂存在于再生上皮中。通过将抗 gicerin 多克隆抗体滴在伤口上，可以抑制移植物对边缘皮肤的粘附性。gicerin-IgG、gicerin-Fc 和 NOF 蛋白的嵌合蛋白促进了移植物的再生。这些发现表明 gicerin 在皮肤自体移植物中的潜在功能，gicerin 和 NOF 蛋白可能有助于移植后的临床改善。
