von Vigier R O, Bianchetti M G
Medizinische Universitäts-Kinderklinik Bern.
Ther Umsch. 1999 Jan;56(1):12-8. doi: 10.1024/0040-5930.56.1.12.
The importance of hypertension in the pediatric population is not as well-appreciated as in adults. This might well be related in part to the lower prevalence of high blood pressure in this age group. As with height and weight, blood pressure increases with age during childhood. 'High normal' blood pressure is a blood pressure above the 90th percentile and established hypertension a blood pressure above 95th percentile. The varying arm and thigh sizes of children and adolescents require blood pressure cuffs that are appropriately sized. A cuff that is too small will produce an artificially elevated blood pressure, while a cuff that is too large is not likely to obscure hypertensive levels of blood pressure. The use of an oscillometric device is more convenient for infants. The underlying causes of significant hypertension in the pediatric population differ considerably from those of adults: while the prevalence of hypertension in pediatrics is lower than in adults, clinically identifiable causes of hypertension account for a much higher proportion of hypertension in children. Children with chronic secondary hypertension will require drug therapy with converting-enzyme inhibitors, calcium-channel blockers, beta-blockers or diuretics. Therapy now tends to be initiated with converting-enzyme inhibitors because they are generally effective and have few side effects. Persistent cough sometimes develops on converting enzyme inhibitors. The term sartans denotes a new group of orally active antagonists of the angiotensin II receptor. Since sartans do not cause cough, these agents represent a promising treatment for patients who develop cough with converting enzyme inhibitors.
高血压在儿科人群中的重要性不像在成人中那样得到充分认识。这很可能部分与该年龄组高血压患病率较低有关。与身高和体重一样,儿童期血压会随着年龄增长而升高。“高正常”血压是指高于第90百分位数的血压,而确诊高血压是指高于第95百分位数的血压。儿童和青少年的手臂和大腿尺寸各不相同,需要使用尺寸合适的血压袖带。袖带过小会人为地使血压升高,而袖带过大则不太可能掩盖高血压水平。对婴儿来说,使用示波装置更方便。儿科人群中严重高血压的潜在病因与成人有很大不同:虽然儿科高血压的患病率低于成人,但临床上可识别的高血压病因在儿童高血压中所占比例要高得多。患有慢性继发性高血压的儿童需要使用转换酶抑制剂、钙通道阻滞剂、β受体阻滞剂或利尿剂进行药物治疗。现在治疗往往从转换酶抑制剂开始,因为它们通常有效且副作用少。使用转换酶抑制剂有时会出现持续性咳嗽。“沙坦类”药物是血管紧张素II受体的一类新型口服活性拮抗剂。由于沙坦类药物不会引起咳嗽,这些药物对因使用转换酶抑制剂而咳嗽的患者来说是一种有前景的治疗方法。