[Delayed-type hypersensitivity in insulin-dependent diabetes mellitus and effects of short-action insulins produced by different pharmaceutical firms].

AIM

The study of activity of T-effector lymphocytes of delayed-type hypersensitivity (DTH) in insulin-dependent diabetes (IDD) and effects of short-action insulins produced by different pharmaceutical firms.

MATERIALS AND METHODS

79 IDD patients aged 3-48 entered the study.

RESULTS

T-effector lymphocytes activity in DTH patients was abnormal: leukocytes migration was enhanced due to inhibited production of the inhibiting factor. Effector function was subnormal. Short-acting insulins promoted normalization of the above indices. The insulins of different producers is individual in efficacy for each patient.

CONCLUSION

In vitro tests are necessary for each patient to determine insulin activity before insulin therapy.