Hodges J R, Patterson K, Ward R, Garrard P, Bak T, Perry R, Gregory C
University of Cambridge Neurology Unit, Addenbrooke's Hospital, United Kingdom.
Neuropsychology. 1999 Jan;13(1):31-40. doi: 10.1037//0894-4105.13.1.31.
The authors compared age-matched groups of patients with the frontal and temporal lobe variants of frontotemporal dementia (FTD; dementia of frontal type [DFT] and semantic dementia), early Alzheimer's disease (AD), and normal controls (n = 9 per group) on a comprehensive neuropsychological battery. A distinct profile emerged for each group: Those with AD showed a severe deficit in episodic memory with more subtle, but significant, impairments in semantic memory and visuospatial skills; patients with semantic dementia showed the previously documented picture of isolated, but profound, semantic memory breakdown with anomia and surface dyslexia but were indistinguishable from the AD group on a test of story recall; and the DFT group were the least impaired and showed mild deficits in episodic memory and verbal fluency but normal semantic memory. The frontal and temporal presentations of FTD are clearly separable from each other and from early AD.
作者在一组全面的神经心理学测试中，对年龄匹配的额颞叶痴呆（FTD；额叶型痴呆[DFT]和语义性痴呆）、早期阿尔茨海默病（AD）患者组以及正常对照组（每组n = 9）进行了比较。每组都呈现出独特的特征：AD患者在情景记忆方面存在严重缺陷，在语义记忆和视觉空间技能方面有更细微但显著的损害；语义性痴呆患者表现出之前记录的孤立但严重的语义记忆衰退，伴有命名障碍和表层失读症，但在故事回忆测试中与AD组没有区别；DFT组受损最轻，在情景记忆和言语流畅性方面有轻度缺陷，但语义记忆正常。FTD的额叶和颞叶表现彼此明显可区分，且与早期AD也可区分。
