Mendez M F, Doss R C, Cherrier M M
Department of Neurology, University of California at Los Angeles, West Los Angeles V.A. Medical Center, 90073, USA.
J Geriatr Psychiatry Neurol. 1998 Spring;11(1):2-6. doi: 10.1177/089198879801100102.
This study investigated the cognitive estimations test (CET) in patients with frontotemporal dementia (FTD) and Alzheimer's disease (AD). The CET consists of questions which reflect judgment and reasoning. FTD patients, who have predominant frontotemporal atrophy, may give more extreme estimates on the CET compared toAD patients, who have greater temporoparietal pathology. The CET was administered to 31 FTD and 31 AD patients of comparable dementia severity plus 31 normal elderly controls. Both dementia groups gave significantly more extreme estimates on the CET than did the controls, and, contrary to expectations, AD patients gave more extreme estimates than did FTD patients. Extreme CET scores correlated with poor savings and calculations scores on neuropsychological tests. In conclusion, the CET may be particularly impaired in AD because it reflects impaired memory and numerical ability as well as disturbed judgment and reasoning. The CET may also be helpful in discriminating some patients in moderate stages of AD from those with FTD.
本研究调查了额颞叶痴呆（FTD）和阿尔茨海默病（AD）患者的认知估计测试（CET）。CET由反映判断和推理的问题组成。与具有更广泛颞顶叶病变的AD患者相比，以额颞叶萎缩为主的FTD患者在CET上可能会给出更极端的估计。对31名痴呆严重程度相当的FTD患者、31名AD患者以及31名正常老年对照者进行了CET测试。两个痴呆组在CET上给出的极端估计均显著多于对照组，并且与预期相反，AD患者给出的极端估计比FTD患者更多。CET极端分数与神经心理测试中的储蓄和计算分数较差相关。总之，CET在AD中可能特别受损，因为它反映了记忆和数字能力受损以及判断和推理紊乱。CET也可能有助于区分AD中度阶段的一些患者与FTD患者。
