Shimamura T, Nakajima M, Iwasaki T, Hayasaki Y, Yonetani Y, Iwaki K
Discovery Research Laboratories, Shionogi & Co., Ltd., Toyonaka, Osaka, Japan.
J Hypertens. 1999 Feb;17(2):211-20. doi: 10.1097/00004872-199917020-00005.
We compared diurnal patterns of blood pressure in Wistar-Kyoto (WKY) rats, spontaneously hypertensive rats (SHR) and stroke-prone spontaneously hypertensive rats (SHRSP), and analyzed the relationship between the change in diurnal patterns of blood pressure and target-organ damage in SHRSP.
Blood pressure, heart rate and motor activity in the three groups of rats were continuously monitored by radiotelemetry, from 1100 h on the first measuring day to 1300 h on the third measuring day. The left ventricular weight and the ratio of beta-myosin heavy chain to alpha-myosin heavy chain in the cardiac left ventricle, morphological changes in the glomerular basement membrane in the kidney, 24 h urinary protein excretion and brain weights were also measured in 10-, 12- or 17-week-old SHRSP.
The SHR circadian blood pressure rhythm exhibited a pattern which peaked during the rats' active (light-off or dark) phase, but the peak time was a little closer to the resting (light-on) phase compared with that for WKY rats. Although the circadian blood pressure rhythm for 10-week-old SHRSP was similar to that observed for SHR, the patterns in 12- and 17-week-old SHRSP were shifted further towards the resting phase. Heart and left ventricular weight increased with the progression of hypertension. The ratio of beta- to alpha-myosin heavy chain in the left ventricle was higher in 12- and 17-week-old SHRSP than in 10-week-old SHRSP. Brain weight was increased significantly in 17-week-old SHRSP compared with 10- and 12-week-old SHRSP. Increased urinary protein excretion and morphological changes in the glomerular basement membrane in the kidney were observed in 12- and 17-week-old SHRSP.
These data suggest that SHRSP have an abnormal circadian blood pressure rhythm associated with hypertensive target-organ damage. This rat strain may therefore be a useful model in which to investigate the mechanisms responsible for the alteration in the circadian blood pressure rhythm, and to analyze the relationship between the abnormal circadian rhythm and target-organ damage.
我们比较了Wistar-Kyoto（WKY）大鼠、自发性高血压大鼠（SHR）和易卒中型自发性高血压大鼠（SHRSP）的血压昼夜模式，并分析了SHRSP血压昼夜模式变化与靶器官损害之间的关系。
通过无线电遥测技术连续监测三组大鼠的血压、心率和运动活动，从第一个测量日的11:00至第三个测量日的13:00。还测量了10周龄、12周龄或17周龄SHRSP的左心室重量以及心脏左心室中β-肌球蛋白重链与α-肌球蛋白重链的比值、肾脏肾小球基底膜的形态变化、24小时尿蛋白排泄量和脑重量。
SHR的昼夜血压节律呈现出在大鼠活动（熄灯或黑暗）期达到峰值的模式，但与WKY大鼠相比，峰值时间更接近休息（开灯）期。虽然10周龄SHRSP的昼夜血压节律与SHR相似，但12周龄和17周龄SHRSP的模式进一步向休息期偏移。心脏和左心室重量随着高血压的进展而增加。12周龄和17周龄SHRSP左心室中β-肌球蛋白重链与α-肌球蛋白重链的比值高于10周龄SHRSP。与10周龄和12周龄SHRSP相比，17周龄SHRSP的脑重量显著增加。在12周龄和17周龄SHRSP中观察到尿蛋白排泄增加和肾脏肾小球基底膜的形态变化。
这些数据表明，SHRSP具有与高血压靶器官损害相关的异常昼夜血压节律。因此，该大鼠品系可能是一个有用的模型，可用于研究昼夜血压节律改变的机制，并分析异常昼夜节律与靶器官损害之间的关系。
