van den Buuse M
Marion Merrell Dow Research Institute, Strasbourg, France.
Physiol Behav. 1994 Apr;55(4):783-7. doi: 10.1016/0031-9384(94)90060-4.
Circadian rhythms of blood pressure, heart rate, and locomotor activity were measured with implanted radio-telemetry transmitters in conscious, unrestrained spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY). During the light period (0600 to 1800 h) systolic, diastolic, and mean blood pressure, heart rate, and locomotor activity were lower than during the dark period (1800 to 0600 h). During the first and the last hour of the dark period, all parameters showed a relative peak when compared to values during the rest of the night. The pattern of circadian changes in blood pressure, heart rate, or behavior was essentially similar in SHR and WKY. Blood pressure values were always higher in SHR than in WKY, but there was no general strain difference in heart rate or locomotor activity values. The administration of hydralazine in the drinking water resulted in a significant decrease in blood pressure in SHR and WKY, and a suppression of the difference between light-phase values and dark-phase values. By contrast, heart rate showed an overall increase in both strains, whereas locomotor activity was largely unaffected. These data show the validity of telemetry as a means of measuring circadian rhythms of blood pressure, heart rate, and behavior in freely moving rats. Apart from their characteristic hypertension, SHR show few differences with WKY with respect to other parameters, such as circadian rhythmicity, baseline heart rate values, or behavior. Some of the previously published differences between SHR and WKY may have been influenced by the stress of the experimental procedures used.
利用植入式无线电遥测发射器，在清醒、无束缚的自发性高血压大鼠（SHR）和Wistar-Kyoto大鼠（WKY）中测量血压、心率和运动活动的昼夜节律。在光照期（06:00至18:00），收缩压、舒张压、平均血压、心率和运动活动均低于黑暗期（18:00至06:00）。在黑暗期的第一个小时和最后一个小时，与夜间其余时间的值相比，所有参数均出现相对峰值。SHR和WKY中血压、心率或行为的昼夜变化模式基本相似。SHR的血压值始终高于WKY，但心率或运动活动值在两品系之间没有普遍差异。饮用水中给予肼屈嗪可使SHR和WKY的血压显著降低，并抑制光期值和暗期值之间的差异。相比之下，两品系的心率总体上均增加，而运动活动基本未受影响。这些数据表明遥测作为测量自由活动大鼠血压、心率和行为昼夜节律的一种方法是有效的。除了其特征性高血压外，SHR在昼夜节律性、基线心率值或行为等其他参数方面与WKY几乎没有差异。之前发表的SHR和WKY之间的一些差异可能受到所用实验程序压力的影响。
