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How does metyrapone decrease seizures?

作者信息

Koch C A, Bornstein S R, Pacak K, Chrousos G P

出版信息

Neurosurg Rev. 1998;21(4):302-3. doi: 10.1007/BF01105791.

DOI:10.1007/BF01105791
PMID:10068196
Abstract
摘要

相似文献

1
How does metyrapone decrease seizures?
Neurosurg Rev. 1998;21(4):302-3. doi: 10.1007/BF01105791.
2
Delay of hormonally induced diabetes by amino-glutethimide and metyrapone in partially pancreatectomized rats bearing transplantable pituitary tumors. Concomitant failure to prevent splanchnomegaly.在患有可移植垂体肿瘤的部分胰腺切除大鼠中,氨基谷氨酰胺和甲吡酮对激素诱导糖尿病的延迟作用。同时未能预防内脏肿大。
Endocrinology. 1970 Jan;86(1):107-19. doi: 10.1210/endo-86-1-107.
3
Metyrapone reduces rat brain damage and seizures after hypoxia-ischemia: an effect independent of modulation of plasma corticosterone levels?
J Cereb Blood Flow Metab. 1998 Apr;18(4):386-90. doi: 10.1097/00004647-199804000-00006.
4
Natural course of febrile seizures.热性惊厥的自然病程。
Pediatrics. 1980 Mar;65(3):680.
5
Management of nonfebrile seizures.非热性惊厥的管理。
Pediatr Rev. 1986 Dec;8(6):185-90. doi: 10.1542/pir.8-6-185.
6
NIH Consensus Development summary. Febrile seizures: long-term management of children with fever-associated seizures.
South Med J. 1980 Nov;73(11):1526.
7
Medical treatment of seizures in children.儿童癫痫的医学治疗。
Dis Nerv Syst. 1971 Oct;32(10):686-9.
8
[Medical management of seizures during infancy and childhood].[婴幼儿及儿童期癫痫发作的医学管理]
Harefuah. 1989 Feb 15;116(4):226-33.
9
Commentary: the Consensus Development Conference on Febrile Seizures.评论:热性惊厥共识发展会议
J Pediatr. 1980 Dec;97(6):933. doi: 10.1016/s0022-3476(80)80423-9.
10
Metyrapone prevents acute glucose hypermetabolism and short-term brain damage induced by intrahippocampal administration of 4-aminopyridine in rats.美替拉酮可预防大鼠海马内注射 4-氨基吡啶引起的急性葡萄糖代谢亢进和短期脑损伤。
Neurochem Int. 2018 Feb;113:92-106. doi: 10.1016/j.neuint.2017.11.018. Epub 2017 Dec 2.

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DHEA inhibits acute microglia-mediated inflammation through activation of the TrkA-Akt1/2-CREB-Jmjd3 pathway.脱氢表雄酮通过激活 TrkA-Akt1/2-CREB-Jmjd3 通路抑制急性小胶质细胞介导的炎症。
Mol Psychiatry. 2018 Jun;23(6):1410-1420. doi: 10.1038/mp.2017.167. Epub 2017 Sep 12.
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New light on an old vitamin: The role of the sunshine vitamin D in chronic disease.旧维生素的新发现:阳光维生素D在慢性病中的作用。
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本文引用的文献

1
[Electroencephalographic studies in convulsions in children].
Pediatrie. 1953;8(5):603-14.
2
Metyrapone reduces rat brain damage and seizures after hypoxia-ischemia: an effect independent of modulation of plasma corticosterone levels?
J Cereb Blood Flow Metab. 1998 Apr;18(4):386-90. doi: 10.1097/00004647-199804000-00006.
3
Is ACTH a key to understanding anticonvulsant action?促肾上腺皮质激素是理解抗惊厥作用的关键吗?
Dev Med Child Neurol. 1998 Feb;40(2):82-9. doi: 10.1111/j.1469-8749.1998.tb15366.x.
4
The CRF1 receptor mediates the excitatory actions of corticotropin releasing factor (CRF) in the developing rat brain: in vivo evidence using a novel, selective, non-peptide CRF receptor antagonist.CRF1受体介导促肾上腺皮质激素释放因子(CRF)在发育中大鼠脑内的兴奋性作用:使用新型、选择性、非肽类CRF受体拮抗剂的体内证据。
Brain Res. 1997 Oct 3;770(1-2):89-95. doi: 10.1016/s0006-8993(97)00759-2.
5
Persistent elevation of corticotrophin releasing factor and vasopressin but not oxytocin mRNA in the rat after kindled seizures.点燃性癫痫发作后大鼠体内促肾上腺皮质激素释放因子和血管加压素的信使核糖核酸持续升高,但催产素的信使核糖核酸未升高。
Neurosci Lett. 1997 Mar 7;224(1):66-70. doi: 10.1016/s0304-3940(97)13455-3.
6
High-dose corticotropin (ACTH) versus prednisone for infantile spasms: a prospective, randomized, blinded study.高剂量促肾上腺皮质激素(ACTH)与泼尼松治疗婴儿痉挛症的前瞻性、随机、双盲研究。
Pediatrics. 1996 Mar;97(3):375-9.
7
Pathophysiology of massive infantile spasms: perspective on the putative role of the brain adrenal axis.巨大婴儿痉挛症的病理生理学:关于脑-肾上腺轴假定作用的观点
Ann Neurol. 1993 Mar;33(3):231-6. doi: 10.1002/ana.410330302.
8
Effect of corticotropin (ACTH) on experimental seizures. Adrenal independence and relation to intracellular brain sodium.促肾上腺皮质激素(ACTH)对实验性癫痫发作的影响。肾上腺独立性及其与脑内细胞内钠的关系。
Neurology. 1965 Dec;15(12):1136-41. doi: 10.1212/wnl.15.12.1136.
9
CRF-induced seizures and behavior: interaction with amygdala kindling.
Brain Res. 1986 May 7;372(2):345-51. doi: 10.1016/0006-8993(86)91142-x.
10
Interactions of ACTH4-10 and ACTH1-24 with L-[3H]glutamate binding sites and GABA/benzodiazepine/picrotoxin receptor complexes in vitro.促肾上腺皮质激素4-10和促肾上腺皮质激素1-24与L-[3H]谷氨酸结合位点及γ-氨基丁酸/苯二氮䓬/印防己毒素受体复合物的体外相互作用。
Brain Dev. 1988;10(2):106-9. doi: 10.1016/s0387-7604(88)80080-9.