Gerhardsson de Verdier M
Department of Clinical Research and Development, Astra Draco AB, Lund, Sweden.
Lakartidningen. 1999 Jan 20;96(3):214-6.
Strong epidemiological evidence suggests relationship to exist between physical inactivity and the risk of large bowel cancer (especially colon cancer). Moreover, there are indications that inactivity is also associated with an increased risk of endogenous hormone-related cancer (especially breast cancer). However, further research is needed to determine whether such relationships are casual, and if so to identify the underlying mechanisms. Since a large proportion of the populations of industrial countries are characterized by a sedentary lifestyle, even a small risk may be associated with high attributable fraction. Moreover, not only are the types of cancer concerned common, but inactivity is also associated with a number of other chronic diseases. Accordingly, the health benefit to be derived from a general increase in physical activity might be substantial.
有力的流行病学证据表明，缺乏身体活动与患大肠癌（尤其是结肠癌）的风险之间存在关联。此外，有迹象表明，缺乏身体活动还与内源性激素相关癌症（尤其是乳腺癌）的风险增加有关。然而，需要进一步研究来确定这种关系是否为因果关系，如果是，则需确定其潜在机制。由于工业化国家的很大一部分人口具有久坐不动的生活方式，即使是很小的风险也可能与高归因比例相关。此外，不仅所涉及的癌症类型很常见，而且缺乏身体活动还与许多其他慢性疾病有关。因此，普遍增加身体活动可能会带来巨大的健康益处。
