Willingham E, Crews D
Department of Zoology, University of Texas at Austin, Austin, Texas, 78712, USA.
Gen Comp Endocrinol. 1999 Mar;113(3):429-35. doi: 10.1006/gcen.1998.7221.
Xenobiotics suspected of being estrogenic-the PCB aroclor 1242 and the pesticides toxaphene, dieldrin, p,p'-DDD, cis-Nonachlor, trans-Nonachlor, p,p'-DDE, and chlordane-were examined for their ability to override a male-producing incubation temperature and result in female hatchlings in the red-eared slider, a turtle with temperature-dependent sex determination. Compounds were assayed in the environmentally relevant concentrations detected in alligator eggs from Lake Apopka, Florida, singly, in concert with one another, and with estradiol. Compounds assayed alone and resulting in significant sex reversal were trans-Nonachlor, cis-Nonachlor, aroclor 1242, p,p'-DDE, and chlordane. When administered with estradiol, only one of the compounds, chlordane, caused sex reversal at significant levels. When applied together, however, the eight compounds assayed resulted in significant sex reversal.
疑似具有雌激素活性的外源性物质——多氯联苯商品名氯丹1242以及杀虫剂毒杀芬、狄氏剂、p,p'-滴滴滴、顺式九氯、反式九氯、p,p'-滴滴伊和氯丹——被检测其是否有能力超越决定雄性的孵化温度，从而在红耳龟（一种具有温度依赖型性别决定的龟类）中产生雌性幼体。这些化合物按照在佛罗里达州阿波普卡湖短吻鳄卵中检测到的与环境相关的浓度进行单独、相互组合以及与雌二醇一起的检测。单独检测时导致显著性别逆转的化合物有反式九氯、顺式九氯、氯丹1242、p,p'-滴滴伊和氯丹。当与雌二醇一起使用时，只有一种化合物氯丹导致了显著水平的性别逆转。然而，当这八种检测的化合物一起应用时，导致了显著的性别逆转。
