Willingham E, Rhen T, Sakata J T, Crews D
Institute of Reproductive Biology, The University of Texas, Austin, TX 78712-1064, USA.
Environ Health Perspect. 2000 Apr;108(4):329-32. doi: 10.1289/ehp.00108329.
Many compounds in the environment capable of acting as endocrine disruptors have been assayed for their developmental effects on morphogenesis; however, few studies have addressed how such xenobiotics affect physiology. In the current study we examine the effects of three endocrine-disrupting compounds, chlordane, trans-nonachlor, and the polychlorinated biphenyl (PCB) mixture Aroclor 1242, on the steroid hormone concentrations of red-eared slider turtle (Trachemys scripta elegans) hatchlings treated in ovo. Basal steroid concentrations and steroid concentrations in response to follicle-stimulating hormone were examined in both male and female turtles treated with each of the three compounds. Treated male turtles exposed to Aroclor 1242 or chlordane exhibited significantly lower testosterone concentrations than controls, whereas chlordane-treated females had significantly lower progesterone, testosterone, and 5[alpha]-dihydrotestosterone concentrations relative to controls. The effects of these endocrine disruptors extend beyond embryonic development, altering sex-steroid physiology in exposed animals.
环境中许多能够充当内分泌干扰物的化合物已被检测其对形态发生的发育影响；然而，很少有研究探讨这类外源性物质如何影响生理学。在本研究中，我们检测了三种内分泌干扰化合物——氯丹、反式九氯和多氯联苯（PCB）混合物Aroclor 1242——对在卵内接受处理的红耳龟（Trachemys scripta elegans）幼体类固醇激素浓度的影响。我们检测了用这三种化合物中的每一种处理的雄性和雌性海龟的基础类固醇浓度以及对促卵泡激素反应后的类固醇浓度。暴露于Aroclor 1242或氯丹的经处理雄性海龟的睾酮浓度显著低于对照组，而经氯丹处理的雌性海龟相对于对照组，其孕酮、睾酮和5α-二氢睾酮浓度显著降低。这些内分泌干扰物的影响不仅限于胚胎发育，还会改变受暴露动物的性类固醇生理学。
