人γ-干扰素基因中CA重复序列多态性与γ-干扰素的体外产生相关。
In vitro production of IFN-gamma correlates with CA repeat polymorphism in the human IFN-gamma gene.
作者信息
Pravica V, Asderakis A, Perrey C, Hajeer A, Sinnott P J, Hutchinson I V
机构信息
School of Biological Sciences, University of Manchester, UK.
出版信息
Eur J Immunogenet. 1999 Feb;26(1):1-3. doi: 10.1046/j.1365-2370.1999.00122.x.
Abstract
The DNA sequence of the human IFN-gamma gene shows the presence of a variable-length CA repeat in the first intron of the gene. We investigated the allele distribution of this microsatellite region in 164 unrelated healthy individuals, and the association with interferon-gamma (IFN-gamma) production. In vitro production of IFN-gamma showed a significant correlation with the presence of allele #2.
摘要
人类干扰素-γ基因的DNA序列显示，该基因的第一个内含子中存在长度可变的CA重复序列。我们研究了164名无亲缘关系的健康个体中该微卫星区域的等位基因分布，以及与干扰素-γ（IFN-γ）产生的相关性。体外IFN-γ的产生与等位基因#2的存在呈显著相关。
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