Schmid M H, Elsner P
Dermatologische Klinik, Universitätsspital Zürich.
Hautarzt. 1999 Jan;50(1):52-5. doi: 10.1007/s001050050865.
Cutaneous adverse drug reactions in HIV-positive patients with their wide spectrum of manifestations remain a diagnostic and therapeutic challenge. Skin diseases as erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis belong to this group. The typical primary lesions are erythematous macules and papules, which rapidly extend to the entire body and may be accompanied by a extensive epidermal detachment. Diagnosis and immediate therapy is indispensable because of the possible fulminant course of the disease. We report a HIV-positive patient with a cutaneous adverse drug reaction showing predominantly hemorrhagic lesions.
HIV 阳性患者的皮肤药物不良反应表现多样,仍然是诊断和治疗上的一大挑战。多形红斑、史蒂文斯 - 约翰逊综合征和中毒性表皮坏死松解症等皮肤病都属于这一类别。典型的原发性皮损为红斑性斑疹和丘疹,它们会迅速蔓延至全身,并且可能伴有大面积表皮剥脱。鉴于该病可能的暴发性病程,诊断和立即治疗必不可少。我们报告了一名 HIV 阳性患者,其皮肤药物不良反应主要表现为出血性皮损。