伐地考昔引起的与史蒂文斯－约翰逊综合征及中毒性表皮坏死松解症不同的皮肤不良反应。
Cutaneous adverse reactions to valdecoxib distinct from Stevens-Johnson syndrome and toxic epidermal necrolysis.
作者信息
Ziemer Mirjana, Wiesend Christiane L, Vetter Robert, Weiss Johannes, Blaschke Sabine, Norgauer Johannes, Mockenhaupt Maja
机构信息
Department of Dermatology, University of Jena, Erfurter Strasse 35, D-07743 Jena, Germany.
出版信息
Arch Dermatol. 2007 Jun;143(6):711-6. doi: 10.1001/archderm.143.6.711.
OBJECTIVE
To assess the type of severe skin reactions caused by valdecoxib treatment.
DESIGN
Case registry of severe skin reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis.
SETTING
All hospitals in Germany that treat patients with severe skin reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis.
PATIENTS
Five case notifications of Stevens-Johnson syndrome after the use of valdecoxib were reevaluated following the withdrawal of valdecoxib on April 7, 2005.
RESULTS
A thorough review of all reported cases of severe skin reactions caused by valdecoxib revealed extensive erythematous, targetlike skin eruptions in addition to facial edema and dyspnea. Histologic changes, clinical pattern, and outcome demonstrated a distinct disease entity.
CONCLUSION
Valdecoxib induces severe skin reactions different from those of Stevens-Johnson syndrome and toxic epidermal necrolysis in clinical and histopathologic findings, course, and outcome.
目的
评估伐地考昔治疗引起的严重皮肤反应类型。
设计
严重皮肤反应（如史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症）病例登记。
地点
德国所有治疗史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症等严重皮肤反应患者的医院。
患者
2005年4月7日停用伐地考昔后，对5例使用伐地考昔后发生史蒂文斯-约翰逊综合征的病例报告进行了重新评估。
结果
对所有报告的由伐地考昔引起的严重皮肤反应病例进行全面审查发现，除面部水肿和呼吸困难外，还有广泛的红斑、靶样皮疹。组织学变化、临床模式和结果显示为一种独特的疾病实体。
结论
在临床和组织病理学表现、病程及结果方面，伐地考昔引起的严重皮肤反应不同于史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症。
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