Epidemic outbreak of Coxsackie virus meningitis. Note II. Virological and serological investigations.

Virological and serological investigations of the viral meningitis cases recorded in a county of Romania in the summer of 1975 demonstrated that in a certain zone (A) the prevalent etiological agent was Coxsackie B3 virus. This virus could be isolated from the feces, exudate or cerebrospinal fluid of some diseased children. At the same time, the appearance of neutralizing antibodies to Coxsackie B3 virus or significant titer increases were observed in 20 of the 25 children tested serologically in zone A.