Patel S, Farrell J, Blades K J, Grierson D J
Academic Unit of Ophthalmology, Birmingham and Midland Eye Centre, City Hospital, UK.
Ophthalmic Physiol Opt. 1998 Nov;18(6):471-6.
To determine the clinical viability of a phenol red impregnated cotton thread in differentiating between normal, aqueous deficient and non-aqueous deficient dry eyes. Subjects were recruited on the basis of subjective symptoms, tear stability, rose bengal staining, Schirmer test, conjunctival hyperaemia, patency and number of meibomian glands, presence of mucin strands, appearance of lower tear meniscus. Based on the outcome of the tests, subjects were categorised as either aqueous deficient dry eyes, non-aqueous dry eyes or normals. Subjects were randomised and a thread was applied by inserting into the lower fornix of the right eye and leaving the thread in place for 120 sec. All data was collected under similar ambient conditions. After gathering all the data, the codes were broken. Mean (+/- S.D.) thread wetting values were, all dry eyes (n = 59) 18.4 mm (5.9). Aqueous deficient dry eyes (n = 35), 15.5 mm (4.6). Non-aqueous deficient dry eyes [n = 24], 22.7 mm (5.0). For the normals (n = 38), 19.4 mm (5.0). Differences between (i) normals and aqueous deficient dry eyes and (ii) aqueous deficient and non-aqueous deficient dry eyes were significant (p = 0.01). Difference between all dry eyes and normals was not significant. For the aqueous deficient and non-aqueous deficient dry eyes only, using a cut-off value of 20 mm the calculated sensitivity and specificity values were 86% and 83% respectively. This cotton thread test can effectively differentiate between aqueous deficient and non-aqueous deficient dry eye.
为确定酚红浸渍棉线在区分正常眼、泪液缺乏性干眼和非泪液缺乏性干眼方面的临床可行性。根据主观症状、泪液稳定性、孟加拉玫瑰红染色、泪液分泌试验、结膜充血、睑板腺通畅情况及数量、粘蛋白丝的存在、下泪液弯月面外观等指标招募受试者。根据测试结果，将受试者分为泪液缺乏性干眼、非泪液缺乏性干眼或正常眼。受试者被随机分组，将一根棉线插入右眼的下穹窿并留置120秒。所有数据均在相似的环境条件下收集。收集完所有数据后，解密编码。棉线湿润值的均值（±标准差）为，所有干眼患者（n = 59）18.4毫米（5.9）。泪液缺乏性干眼患者（n = 35），15.5毫米（4.6）。非泪液缺乏性干眼患者[n = 24]，22.7毫米（5.0）。正常眼（n = 38），19.4毫米（5.0）。（i）正常眼与泪液缺乏性干眼之间以及（ii）泪液缺乏性干眼与非泪液缺乏性干眼之间的差异具有统计学意义（p = 0.01）。所有干眼患者与正常眼之间的差异无统计学意义。仅对于泪液缺乏性干眼和非泪液缺乏性干眼，使用20毫米的临界值，计算出的敏感度和特异度值分别为86%和83%。这种棉线试验可以有效区分泪液缺乏性干眼和非泪液缺乏性干眼。
