Busetti A, Soncin M, Jori G, Rodgers M A
Department of Biology, University of Padova, Italy.
Br J Cancer. 1999 Feb;79(5-6):821-4. doi: 10.1038/sj.bjc.6690131.
Benzoporphyrin derivative monoacid ring A (verteporfin, BPD-MA) when intravenously injected (5.5 micromol kg(-1)) to C57/BL6 mice bearing a subcutaneously transplanted B1 melanoma gave a maximal accumulation in the tumour within 1-3 h with recoveries of 1.84-1.96 micromol kg(-1). Irradiation of BPD-MA-loaded melanoma with 690-nm light from a dye laser at 3 h and 9 h post injection induced tumour necrosis and delay of tumour growth of 28 and 14 days respectively. The response of the tumour to BPD-MA photosensitization was enhanced by pretreatment with 1064-nm light from a pulse-operated Nd:YAG laser, which caused a selective breakdown of melanosomes.
将苯并卟啉衍生物单酸环A(维替泊芬,BPD-MA)以5.5微摩尔/千克的剂量静脉注射到皮下移植有B1黑色素瘤的C57/BL6小鼠体内后,在1至3小时内肿瘤内积累量达到最大,回收率为1.84至1.96微摩尔/千克。在注射后3小时和9小时,用染料激光发出的690纳米光照射负载有BPD-MA的黑色素瘤,分别诱导肿瘤坏死并使肿瘤生长延迟28天和14天。用脉冲操作的Nd:YAG激光发出的1064纳米光进行预处理可增强肿瘤对BPD-MA光致敏的反应,这会导致黑素体的选择性分解。