Benazzi F
Department of Psychiatry Public Hospital Morgagni Forli, Italy.
Pharmacopsychiatry. 1999 Jan;32(1):41. doi: 10.1055/s-2007-979187.
Gynecomastia (breast enlargement) is a side effect of neuroleptic antipsychotic drugs, related to prolactin elevation caused by dopamine D2 receptor blockade (Richelson, 1996). The atypical antipsychotic risperidone is less likely to cause gynecomastia at low doses (Casey, 1996). It can cause a dose-dependent increase in serum prolactin concentration (Peuskens, 1995), by blocking dopamine D2 receptors (Richelson, 1996). I would like to describe a patient who did not have gynecomastia with risperidone at a dose of 3 mg/day, but had it when risperidone, at a dose of 0.5 mg/day, was combined with fluoxetine. A MEDLINE search failed to find any reports about such an interaction.
男性乳房增生（乳腺增大）是抗精神病药物的一种副作用，与多巴胺D2受体阻断导致的催乳素升高有关（里克尔森，1996年）。非典型抗精神病药物利培酮在低剂量时引发男性乳房增生的可能性较小（凯西，1996年）。它可通过阻断多巴胺D2受体导致血清催乳素浓度呈剂量依赖性升高（佩斯肯斯，1995年）（里克尔森，1996年）。我想描述一位患者，他服用3毫克/天的利培酮时未出现男性乳房增生，但当0.5毫克/天的利培酮与氟西汀合用时却出现了这种情况。对医学文献数据库（MEDLINE）的检索未发现任何有关这种相互作用的报告。
