Staub M
Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézet, Semmelweis Orvostudományi Egyetem.
Orv Hetil. 1999 Feb 7;140(6):275-9.
Uric acid, the naturally occurring product of purine metabolism, is widely used as a diagnostic parameter in different diseases. The concentration of uric acid may vary between broad ranges without causing symptoms, like idiopathic hyperuricemia, which behind metabolic disorders were always suggested. Recently the uric acid has been shown as a strong scavenger of oxidative stress molecules or radicals. Uric acid was successfully used to treat experimental allergic encephalomyelitis, the mouse model of multiple sclerosis (M. S.). It was shown, that patients with multiple sclerosis had significantly lower levels of serum uric acid than the control persons. In addition, statistical evaluation of more than 20 million patient records for the incidence of MS and hyperuricemic gout revealed, that the hyperuricemia may protect against MS.
尿酸是嘌呤代谢的天然产物，在不同疾病中广泛用作诊断参数。尿酸浓度可在很宽的范围内变化而不引起症状，如特发性高尿酸血症，其背后总是提示存在代谢紊乱。最近，尿酸已被证明是氧化应激分子或自由基的强清除剂。尿酸已成功用于治疗实验性变应性脑脊髓炎，即多发性硬化症（MS）的小鼠模型。结果表明，多发性硬化症患者的血清尿酸水平明显低于对照组。此外，对2000多万份关于MS发病率和高尿酸血症痛风患者记录的统计评估显示，高尿酸血症可能预防MS。
