Abdelrahim F, Mostafa A, Hamdy A, Mabrouk M, el-Kholy M, Hassan O
Department of Urology, Al-Azhar University, Cairo, Egypt.
Br J Urol. 1993 Nov;72(5 Pt 1):643-7. doi: 10.1111/j.1464-410x.1993.tb16225.x.
The organic effects of varicocele on testicular histology were studied in bilateral testicular biopsies obtained from 30 infertile men during varicocele repair and 3 to 6 months post-operatively, using light microscopy. Before surgery and at follow-up, semen analyses were performed. The results showed a substantial improvement in semen quality in 22 cases post-operatively. Pre-operative biopsies showed depressed spermatogenesis with a predominant picture of maturation arrest, sloughing of spermatogenic epithelium, an increase in Leydig cells, thickening of tubular basement membranes and interstitial blood vessel walls with narrowing of their lumina, and increased deposition of interstitial fibrous tissue. Post-operatively, spermatogenesis improved in 22 cases, with increased mean tubular scores together with diminution in epithelial cell sloughing. The increased prominence of Leydig cells reverted to normal in 18 cases. The changes in tubular basement membranes, interstitium and interstitial blood vessels were unaffected.
在精索静脉曲张修复手术期间及术后3至6个月，对30例不育男性进行双侧睾丸活检，利用光学显微镜研究精索静脉曲张对睾丸组织学的器质性影响。手术前及随访时均进行精液分析。结果显示，术后22例患者的精液质量有显著改善。术前活检显示生精功能低下，主要表现为成熟停滞、生精上皮脱落、间质细胞增多、管状基底膜和间质血管壁增厚伴管腔狭窄，以及间质纤维组织沉积增加。术后，22例患者的生精功能得到改善，平均管腔评分增加，上皮细胞脱落减少。18例患者间质细胞增多的情况恢复正常。管状基底膜、间质和间质血管的变化未受影响。
