Becker S I, Smalligan R D, Frame J D, Kleanthous H, Tibbitts T J, Monath T P, Hyams K C
Duke University School of Medicine, Durham, North Carolina, USA.
Am J Trop Med Hyg. 1999 Feb;60(2):267-70. doi: 10.4269/ajtmh.1999.60.267.
The seroprevalence and incidence of Helicobacter pylori infection were determined among 312 North American missionaries who were serving in developing countries between 1967 and 1984. The majority (81%) resided in sub-Saharan Africa. When initially evaluated, the missionaries had a mean age of 40 years, 65% were female, and all were of white race/ethnicity. An ELISA showed that the initial prevalence of IgG antibody to H. pylori was 17%. After a mean of 7.4 years of service (1917 person-years of exposure), 37 (14%) of 259 initially seronegative subjects seroconverted to anti-H. pylori, giving an annual incidence of 1.9%. These data indicate a relatively higher risk of H. pylori infection among missionaries compared with an annual incidence of seroconversion of 0.3-1.0% in industrialized nations. Long-term residents in developing countries should be evaluated for H. pylori infection when gastrointestinal symptoms develop.
1967年至1984年间，对312名在发展中国家服务的北美传教士进行了幽门螺杆菌感染的血清流行率和发病率测定。大多数人（81%）居住在撒哈拉以南非洲。初次评估时，传教士的平均年龄为40岁，65%为女性，且均为白人种族/族裔。酶联免疫吸附测定（ELISA）显示，幽门螺杆菌IgG抗体的初始流行率为17%。经过平均7.4年的服务（1917人年暴露时间），259名初始血清阴性的受试者中有37人（14%）血清转化为抗幽门螺杆菌抗体，年发病率为1.9%。这些数据表明，与工业化国家0.3-1.0%的血清转化率年发病率相比，传教士感染幽门螺杆菌的风险相对较高。发展中国家的长期居民出现胃肠道症状时，应评估是否感染幽门螺杆菌。
