de Silva A M, Dittus W P, Amerasinghe P H, Amerasinghe F P
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Am J Trop Med Hyg. 1999 Feb;60(2):300-6. doi: 10.4269/ajtmh.1999.60.300.
Dengue is one of the most rapidly emerging diseases in the tropics. Humans are the principal reservoir of dengue viruses. It is unclear if nonhuman primates also serve as a reservoir of human dengue viruses under certain conditions. In this study, a cross-sectional serologic survey was carried out to characterize the pattern of transmission of a recently identified dengue virus among toque macaques in Sri Lanka. The results indicated that an epizootic dengue virus was active among the macaques. A single epizootic had taken place between October 1986 and February 1987 during which 94% of the macaques within the 3 km2 study site were exposed to the virus. The epizootic was highly focal in nature because macaques living 5 km from the study population were not exposed to the virus. The transmission of dengue viruses among macaques in the wild may have important public health implications.
登革热是热带地区迅速出现的疾病之一。人类是登革热病毒的主要宿主。尚不清楚在某些情况下，非人灵长类动物是否也作为人类登革热病毒的宿主。在本研究中，开展了一项横断面血清学调查，以描述最近在斯里兰卡的斯里兰卡猕猴中发现的一种登革热病毒的传播模式。结果表明，一种流行性登革热病毒在猕猴中活跃传播。1986年10月至1987年2月间发生了一次单一的动物疫情，在此期间，3平方公里研究区域内94%的猕猴接触到了该病毒。该疫情在本质上具有高度的局限性，因为生活在距离研究种群5公里处的猕猴没有接触到该病毒。野生猕猴中登革热病毒的传播可能对公共卫生具有重要意义。
