Zaitsev VS, Filimonov DS, Presnyakov IA, Gambino RJ, Chu B
Department of Chemistry, State University of New York at Stony Brook, Stony Brook, New York, 11794-3400
J Colloid Interface Sci. 1999 Apr 1;212(1):49-57. doi: 10.1006/jcis.1998.5993.
The properties of polymer-coated magnetite nanoparticles, which have the potential to be used as effective magnetic resonance contrast agents, have been studied. The magnetite particles were synthesized by using continuous synthesis in an aqueous solution. The polymer-coated magnetite nanoparticles were synthesized by seed precipitation polymerization of methacrylic acid and hydroxyethyl methacrylate in the presence of the magnetite nanoparticles. The particle size was measured by laser light scattering. It was shown that the particle size, variance, magnetic properties, and stability of aqueous magnetite colloidal dispersion strictly depend on the nature of the stabilizing agent. The average hydrodynamic radius of the magnetite particles was found to be 5.7 nm in the stable aqueous colloidal dispersion. An inclusion of the magnetite particle into a hydrophilic polymeric shell increases the stability of the dispersion and decreases the influence of the stabilizing agent on the magnetic and structural properties of the magnetite particles as was shown by X-ray diffraction and Mössbauer and IR spectroscopy, as well as by vibrating sample magnetometry. The variation in the polymeric shell size and the polymer net density can be useful tools for evaluation of the polymer-coated magnetite particles as effective contrast agents. Copyright 1999 Academic Press.
对有可能用作有效磁共振造影剂的聚合物包覆磁铁矿纳米颗粒的性质进行了研究。磁铁矿颗粒是通过在水溶液中连续合成制备的。聚合物包覆磁铁矿纳米颗粒是在磁铁矿纳米颗粒存在的情况下，通过甲基丙烯酸和甲基丙烯酸羟乙酯的种子沉淀聚合反应合成的。通过激光散射测量颗粒尺寸。结果表明，磁铁矿水胶体分散体的颗粒尺寸、方差、磁性和稳定性严格取决于稳定剂的性质。在稳定的水胶体分散体中，磁铁矿颗粒的平均流体动力学半径为5.7纳米。如X射线衍射、穆斯堡尔谱和红外光谱以及振动样品磁强计所示，将磁铁矿颗粒包入亲水性聚合物壳层可提高分散体的稳定性，并降低稳定剂对磁铁矿颗粒磁性和结构性质的影响。聚合物壳层尺寸和聚合物网络密度的变化可能是评估聚合物包覆磁铁矿颗粒作为有效造影剂的有用工具。版权所有1999年学术出版社。
