Siddiqi Khwaja Salahuddin, Ur Rahman Aziz, Husen Azamal
Department of Chemistry, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India.
Department of Saidla (Unani Pharmacy), Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India.
Nanoscale Res Lett. 2016 Dec;11(1):498. doi: 10.1186/s11671-016-1714-0. Epub 2016 Nov 11.
Enshrined in this review are the biogenic fabrication and applications of coated and uncoated iron and iron oxide nanoparticles. Depending on their magnetic properties, they have been used in the treatment of cancer, drug delivery system, MRI, and catalysis and removal of pesticides from potable water. The polymer-coated iron and iron oxide nanoparticles are made biocompatible, and their slow release makes them more effective and lasting. Their cytotoxicity against microbes under aerobic/anaerobic conditions has also been discussed. The magnetic moment of superparamagnetic iron oxide nanoparticles changes with their interaction with biomolecules as a consequence of which their size decreases. Their biological efficacy has been found to be dependent on the shape, size, and concentration of these nanoparticles.
本文综述了包覆和未包覆的铁及氧化铁纳米颗粒的生物制造及其应用。根据其磁性，它们已被用于癌症治疗、药物递送系统、磁共振成像、催化以及从饮用水中去除农药。聚合物包覆的铁和氧化铁纳米颗粒具有生物相容性，其缓释特性使其更有效且持久。还讨论了它们在需氧/厌氧条件下对微生物的细胞毒性。超顺磁性氧化铁纳米颗粒的磁矩会随着它们与生物分子的相互作用而改变，其尺寸也会因此减小。已发现它们的生物学功效取决于这些纳米颗粒的形状、大小和浓度。
