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[临床条件下使用非抗生素治疗慢性肾盂肾炎急性加重期的结果]

[Results of treatment of chronic exacerbated pyelonephritis with unroantiseptics under clinical conditions].

作者信息

Todorova L, Belovezhdov N, Neshev K H, Peneva S

出版信息

Vutr Boles. 1976;15(4):67-73.

PMID:1007240
Abstract

The results are reported from the carried out 701 shortterm therapeutic courses in 527 patients with exacerbated chronic pyelonephritis. The results are considered as "very good" in realization of a full clinical remission (normalization of temperature and ESR), disappearance of leucocyturia and bacteriuria), "good" - in normalization of three of those indices and "withfut effect". Co-trimoxazol (88.3 per cent of the patients), gentamycin (61.7%), ampicillin (58.8%), nelidix acid (57.4%), nitrfuran (55.0%) and choloramphenicol (53.1%) have manifested the highest effectiveness (very good and good effect). In a small number of the treated patients with cephalosporins effect was obtained in 50.0 per cent, with urovalidin - 44.4 per cent and with carbenicillin - 62.5 per cent. According to the authors' opinion the therapeutic schemes for a long-term treatment must include chlorampheniacal, nelidix acid, co-trimoxazol and nitrofuran sometives -amplicillin. Gentamycin, ampicillin and cephalosporins and with indications - some other uroantiseptics must be used in the coping with severe exacerbation of the disease. The authors recommend the chronic intermittent uroantiseptic treatment.

摘要

报告了对527例慢性肾盂肾炎急性发作患者进行的701个短期治疗疗程的结果。若实现完全临床缓解(体温和血沉正常、白细胞尿和菌尿消失),则结果视为“非常好”;若上述三项指标中的三项恢复正常,则视为“好”;若“无效果”。复方新诺明(88.3%的患者)、庆大霉素(61.7%)、氨苄西林(58.8%)、萘啶酸(57.4%)、呋喃妥因(55.0%)和氯霉素(53.1%)显示出最高的有效性(非常好和好的效果)。在少数接受头孢菌素治疗的患者中,有效率为50.0%,使用乌洛托品的有效率为44.4%,使用羧苄西林的有效率为62.5%。作者认为,长期治疗方案必须包括氯霉素、萘啶酸、复方新诺明和呋喃妥因,有时还包括氨苄西林。庆大霉素、氨苄西林和头孢菌素,以及在有指征时使用的其他一些尿路抗菌药,必须用于应对疾病的严重急性发作。作者推荐慢性间歇性尿路抗菌治疗。

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