Todorova L, Belovezhdov N, Neshev K H, Peneva S
Vutr Boles. 1976;15(4):67-73.
The results are reported from the carried out 701 shortterm therapeutic courses in 527 patients with exacerbated chronic pyelonephritis. The results are considered as "very good" in realization of a full clinical remission (normalization of temperature and ESR), disappearance of leucocyturia and bacteriuria), "good" - in normalization of three of those indices and "withfut effect". Co-trimoxazol (88.3 per cent of the patients), gentamycin (61.7%), ampicillin (58.8%), nelidix acid (57.4%), nitrfuran (55.0%) and choloramphenicol (53.1%) have manifested the highest effectiveness (very good and good effect). In a small number of the treated patients with cephalosporins effect was obtained in 50.0 per cent, with urovalidin - 44.4 per cent and with carbenicillin - 62.5 per cent. According to the authors' opinion the therapeutic schemes for a long-term treatment must include chlorampheniacal, nelidix acid, co-trimoxazol and nitrofuran sometives -amplicillin. Gentamycin, ampicillin and cephalosporins and with indications - some other uroantiseptics must be used in the coping with severe exacerbation of the disease. The authors recommend the chronic intermittent uroantiseptic treatment.
报告了对527例慢性肾盂肾炎急性发作患者进行的701个短期治疗疗程的结果。若实现完全临床缓解(体温和血沉正常、白细胞尿和菌尿消失),则结果视为“非常好”;若上述三项指标中的三项恢复正常,则视为“好”;若“无效果”。复方新诺明(88.3%的患者)、庆大霉素(61.7%)、氨苄西林(58.8%)、萘啶酸(57.4%)、呋喃妥因(55.0%)和氯霉素(53.1%)显示出最高的有效性(非常好和好的效果)。在少数接受头孢菌素治疗的患者中,有效率为50.0%,使用乌洛托品的有效率为44.4%,使用羧苄西林的有效率为62.5%。作者认为,长期治疗方案必须包括氯霉素、萘啶酸、复方新诺明和呋喃妥因,有时还包括氨苄西林。庆大霉素、氨苄西林和头孢菌素,以及在有指征时使用的其他一些尿路抗菌药,必须用于应对疾病的严重急性发作。作者推荐慢性间歇性尿路抗菌治疗。