Yabe S, Nishizawa H, Egawa H, Nakayama H, Okamoto S, Kiuchi T, Uemoto S, Asonuma K, Shapiro A M, Inomata Y, Yamaoka Y, Tanaka K
Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Eur Surg Res. 1999;31(1):83-92. doi: 10.1159/000008624.
Functional competition has been shown to lead to a detrimental outcome in auxiliary liver transplantation. We evaluated the interaction in auxiliary partial orthotopic liver transplantation between the native liver and the graft in terms of portal flow and regeneration. The need for diversion of the portal flow to the graft was also assessed. Reduced-size liver grafts were transplanted orthotopically after partial hepatectomy in beagles. There were two groups: the preserved group, where portal inflow to the native liver was preserved, and the ligated group, where it was interrupted. Portal flow was measured serially and liver regeneration was evaluated on postoperative day 5. Functional competition was not observed in the preserved group. On the other hand, ligation of the native liver portal vein had no obviously detrimental effects on the remnant native liver. This leads to the conclusion that the portal vein to the native liver can be safely ligated to prevent functional competition.
在辅助性肝移植中，功能竞争已被证明会导致有害结果。我们从门静脉血流和再生方面评估了辅助性部分原位肝移植中天然肝脏与移植物之间的相互作用。还评估了将门静脉血流分流至移植物的必要性。在比格犬部分肝切除术后将缩小体积的肝移植物原位移植。分为两组：保留组，保留天然肝脏的门静脉流入；结扎组，中断门静脉流入。连续测量门静脉血流，并在术后第5天评估肝脏再生情况。在保留组中未观察到功能竞争。另一方面，结扎天然肝脏门静脉对残余天然肝脏没有明显的有害影响。由此得出结论，可安全结扎天然肝脏的门静脉以防止功能竞争。
