Roy A
Psychiatry Service, Department of Veterans Affairs, New Jersey Healthcare System, East Orange, NJ 07019, USA.
Neuropsychobiology. 1999;39(2):71-5. doi: 10.1159/000026563.
Suicidal behavior in depressed patients is associated with low central serotonin. Thus, platelet serotonin uptake in relation to suicidal behavior in depression was examined.
Depressed patients who had never attempted suicide (n = 23) were compared with depressed patients who had never attempted suicide (n = 26) and normal controls (n = 71) for platelet serotonin uptake.
Depressed patients who had a lifetime history of a suicide attempt had a significantly greater apparent Michaelis constant (Km) of platelet serotonin uptake than either depressed patients who had never attempted suicide or controls. Patients rated high for current suicidal ideation at the index admission had significantly higher Km values than patients rated low. Also, patients who reattempted or committed suicide during a 5-year follow-up period had significantly higher Km values than controls. Among women patients who had attempted suicide there was a significant correlation between extrapunitive hostility scores and Km values.
The serotonin transporter warrants further study in relation to suicidal behavior in depression.
抑郁症患者的自杀行为与中枢血清素水平低有关。因此，研究了血小板血清素摄取与抑郁症自杀行为的关系。
将从未有过自杀未遂的抑郁症患者（n = 23）与从未有过自杀未遂的抑郁症患者（n = 26）及正常对照者（n = 71）进行血小板血清素摄取情况的比较。
有过自杀未遂终生史的抑郁症患者血小板血清素摄取的表观米氏常数（Km）显著高于从未有过自杀未遂的抑郁症患者或对照组。在首次入院时当前自杀观念评分高的患者的Km值显著高于评分低的患者。此外，在5年随访期间再次自杀未遂或自杀的患者的Km值显著高于对照组。在有过自杀未遂的女性患者中，外罚性敌意得分与Km值之间存在显著相关性。
血清素转运体在抑郁症自杀行为方面值得进一步研究。
