Department of Laboratory Diagnostics, Sveti Ivan Psychiatric Hospital, Jankomir 11, 10 000 Zagreb, Croatia.
Magnes Res. 2013 Jan-Feb;26(1):9-17. doi: 10.1684/mrh.2013.0332.
The pathophysiology and treatment of depression involves monoamine neurotransmitters and the magnesium (Mg)-modulated monoaminergic pathway. Serum and platelet Mg concentrations and platelet serotonin concentrations were measured in 79 depressed patients who had attempted suicide, and 101 patients without suicidal behaviour, according to the ICD-10 diagnoses F 33.2 and F32.2, with or without intentional self-harm (X60-X84). The control group consisted of 77 voluntary blood donors. The platelet serotonin concentration was determined using the competitive enzyme immunoassay test: Mg concentrations in platelets and serum were determined by atomic absorption spectrophotometry. The ANOVA test showed significantly lower serum Mg in the group of depressive patients who had attempted suicide (N = 257, F = 8.32, p<0.001), compared to depressive patients who had not, and the control group. Serum albumin was lower in the group of depressive patients who had attempted suicide and showed a significant, positive correlation with serum Mg concentrations. Platelet Mg concentrations were found to be higher in depressive patients who had not attempted suicide (N = 257, F = 3.90, p = 0.012) compared to the control group, with no difference compared to depressive patients who had attempted suicide. The Kruskal Wallis test (N = 257, H = 48.54, p<0.0001) showed the lowest concentration of platelet serotonin in the groups of depressed patients with and without suicidal behaviour, compared to the healthy control group. A positive correlation was found between platelet Mg and serotonin concentrations only in the healthy control group. In conclusion, differences were observed in serum and platelet Mg concentrations, which represent progress in the study of Mg status and its relation to serotonin.
抑郁症的病理生理学和治疗涉及单胺神经递质和镁（Mg）调节的单胺能途径。根据 ICD-10 诊断 F 33.2 和 F32.2，对 79 名有自杀企图的抑郁症患者和 101 名无自杀行为的患者进行了血清和血小板 Mg 浓度以及血小板 5-羟色胺浓度的测量，伴有或不伴有故意自残（X60-X84）。对照组由 77 名自愿献血者组成。使用竞争酶免疫测定法测定血小板 5-羟色胺浓度：用原子吸收分光光度法测定血小板和血清中的 Mg 浓度。方差分析显示，有自杀企图的抑郁症患者组的血清 Mg 显著低于无自杀企图的抑郁症患者组（N=257，F=8.32，p<0.001），也显著低于对照组。有自杀企图的抑郁症患者组的血清白蛋白水平较低，且与血清 Mg 浓度呈显著正相关。发现无自杀企图的抑郁症患者组的血小板 Mg 浓度较高（N=257，F=3.90，p=0.012），与对照组相比无差异，与有自杀企图的抑郁症患者组相比也无差异。Kruskal Wallis 检验（N=257，H=48.54，p<0.0001）显示，有和无自杀行为的抑郁症患者组的血小板 5-羟色胺浓度均低于健康对照组。只有在健康对照组中，才发现血小板 Mg 和 5-羟色胺浓度之间存在正相关。总之，观察到血清和血小板 Mg 浓度存在差异，这代表了 Mg 状态及其与 5-羟色胺关系的研究进展。
