[Expression of FGF-b and C-myc in rats lung tissue affected by hypoxia].

OBJECTIVE

To study FGF's roles in the reconstruction of vascular walls owing to chronic hypoxia.

METHOD

40 SD rats [corrected] were divided into different hypoxia groups and proceeded with various hypoxic intervals. Expression of FGF-b and transcription of c-myc mRNA of the rats [corrected] lung tissues were detected by immunohistochemical method and in situ hybridization.

RESULTS

FGF-b increased obviously in the smooth muscle and advential tissue of pulmonary arteries after 14 days of hypoxia, whereas C-myc mRNA showed overexpression in rats [corrected] lung tissue from 7th to 21st day of hypoxia.

CONCLUSION

(1) Hypoxia may lead to activation of C-myc oncogene and increase of FGF-b expression in lung tissue. (2) FGF-b and C-myc oncogene takes part in reconstruction of pulmonary arterial wall affected by chronic hypoxia.