Ouyang N, Ran P, Du Z
Guangzhou Institute for Respiratory Disease.
Zhonghua Jie He He Hu Xi Za Zhi. 1997 Feb;20(1):22-4.
To study FGF's roles in the reconstruction of vascular walls owing to chronic hypoxia.
40 SD rats [corrected] were divided into different hypoxia groups and proceeded with various hypoxic intervals. Expression of FGF-b and transcription of c-myc mRNA of the rats [corrected] lung tissues were detected by immunohistochemical method and in situ hybridization.
FGF-b increased obviously in the smooth muscle and advential tissue of pulmonary arteries after 14 days of hypoxia, whereas C-myc mRNA showed overexpression in rats [corrected] lung tissue from 7th to 21st day of hypoxia.
(1) Hypoxia may lead to activation of C-myc oncogene and increase of FGF-b expression in lung tissue. (2) FGF-b and C-myc oncogene takes part in reconstruction of pulmonary arterial wall affected by chronic hypoxia.
研究成纤维细胞生长因子（FGF）在慢性缺氧所致血管壁重建中的作用。
将40只SD大鼠分为不同的缺氧组，并给予不同的缺氧时间。采用免疫组织化学法和原位杂交法检测大鼠肺组织中FGF-b的表达及c-myc mRNA的转录情况。
缺氧14天后，肺动脉平滑肌和外膜组织中的FGF-b明显增加，而在缺氧第7天至第21天，大鼠肺组织中的C-myc mRNA呈过表达。
（1）缺氧可能导致肺组织中C-myc癌基因激活及FGF-b表达增加。（2）FGF-b和C-myc癌基因参与慢性缺氧所致肺动脉壁的重建。
