[Clinical and pathological analysis of liver injury resulting from rifampin and isoniazid].

OBJECTIVE

To explore the relationship between clinical manifestations and pathological changes of liver injury resulting from rifampin and isoniazid.

METHOD

194 cases treated with rifampin and isoniazid, among them liver biopsies were done once in 28 cases, twice in 17 cases, were observed.

RESULTS

21 of 59 cases with positive HBVM and 13 out of 135 cases with negative HBVM showed abnormal liver function after treatment, and the elevation of ALT was in accordance with the degree of liver pathological injury. Elevated ALT and liver pathological injury returned to normal within 6 weeks after rifampin and isoniazid were stopped or reduced in doses. No significant difference was found between chronic hepatis B and rifampin, isoniazid in causing liver pathological injury, but two different points were noted in their manifestations: 1. The cells mainly caused portal inflammation were lymphocytes in the former, while eosinophils in the latter. 2. The incidence of intrahepatic cholestasis was higher in the latter.

CONCLUSION

The incidence of liver injury in HBVM positive group is higher than that in HBVM negative group because liver injury exists in the former before treatment, and the mechanisms causing liver injury may be different.