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[抗结核药物对乙肝病毒标志物阳性患者肝功能的影响]

[The impact of antituberculosis drugs upon liver function in patients with positive HBVM].

作者信息

Chen G Q

出版信息

Zhonghua Jie He He Hu Xi Za Zhi. 1989 Apr;12(2):89-90, 126.

PMID:2791129
Abstract

Through the liver function analysis of 100 tuberculosis cases in the course of antituberculosis chemotherapy the authors found that the abnormal liver function rate turned to be 50% in the positive HBVM Group but only 2.4% in the negative, HBVM Group. There is a significant statistical difference between the two groups of cases (P less than 0.01). For this reason, the authors suggested the HBVM should be determined one by one before taking the antituberculosis chemotherapy in the area with high incidence of B-type hepatitis, the data indicated clearly that, the abnormal phenomena of liver function after the antituberculosis treatment for those patients, mainly caused by the drugs.

摘要

通过对100例肺结核患者抗结核化疗过程中的肝功能分析,作者发现,乙肝病毒标志物(HBVM)阳性组肝功能异常率为50%,而HBVM阴性组仅为2.4%。两组病例之间存在显著统计学差异(P<0.01)。因此,作者建议,在乙型肝炎高发地区,抗结核化疗前应逐一检测HBVM。数据清楚表明,这些患者抗结核治疗后出现的肝功能异常现象主要由药物引起。

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