[浸润性乳腺癌的预后、转移与微血管数量之间的关系]
[The relationship between prognosis, metastasis and microvessel quantity in invasive breast carcinoma].
作者信息
Cheng J, Lin H, Liang X
机构信息
Department of Pathology, Sixth People's Hospital, Guangzhou.
出版信息
Zhonghua Bing Li Xue Za Zhi. 1997 Jun;26(3):158-60.
OBJECTIVE
To determine the prognostic value and relationship of microvessel quantity (MVQ) with PCNA, c-erbB-2, nm23-H1 and Cathepsin D in invasive breast carcinoma.
METHODS
Immunohistochemical techniques (LSAB) were used to detect the expression of PCNA, c-erbB-2, nm23-H1, Cathepsin D and MVQ in 76 cases of invasive breast carcinoma.
RESULTS
The mean of MVQ was 57.82 +/- 22.22 in 76 cases of invasive breast carcinoma. The expression of Cathepsin D (cancer cells), c-erbB-2 and node positive were not related to MVQ. MVQ was positively correlated to expression of Cathepsin D (stroma cells), PCNA and distant metastasis (10 years), but negatively correlated to 5 year survival.
CONCLUSION
MVQ was significantly correlated to distant metastasis and survival period in invasive breast carcinoma. MVQ may be an independant prognostic indicator.
目的
确定微血管数量（MVQ）在浸润性乳腺癌中的预后价值及其与增殖细胞核抗原（PCNA）、c-erbB-2、nm23-H1和组织蛋白酶D的关系。
方法
采用免疫组织化学技术（LSAB法）检测76例浸润性乳腺癌中PCNA、c-erbB-2、nm23-H1、组织蛋白酶D的表达及MVQ。
结果
76例浸润性乳腺癌MVQ均值为57.82±22.22。组织蛋白酶D（癌细胞）、c-erbB-2的表达及淋巴结阳性与MVQ无关。MVQ与组织蛋白酶D（基质细胞）、PCNA的表达及远处转移（10年）呈正相关，而与5年生存率呈负相关。
结论
MVQ与浸润性乳腺癌的远处转移及生存期显著相关。MVQ可能是一个独立的预后指标。
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