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[肿瘤坏死因子与肾小球系膜细胞之间的关系]

[The relationship between tumor necrosis factor and glomerular mesangial cells].

作者信息

Liu Z, Zou W

机构信息

Department of Pathology, Beijing Medical University.

出版信息

Zhonghua Bing Li Xue Za Zhi. 1997 Aug;26(4):203-6.

PMID:10072863
Abstract

OBJECTIVE

To study the autocrine function of tumor necrosis factor (TNF) in glomerular mesangial cells (MC) and the action of TNF on MC.

METHODS

Cultured rat and human MC were studied by RT-PCR, in situ hybridization and immunohistochemical methods.

RESULTS

The expression of both TNF and TNF receptor mRNA and protein synthesis in MC were manifested.

CONCLUSION

(1) MC is the target cell for TNF, MC have specific cell surface receptor to TNF. (2) TNF acts on MC through both autocrine and paracrine mechanism.

摘要

目的

研究肿瘤坏死因子（TNF）在肾小球系膜细胞（MC）中的自分泌功能以及TNF对MC的作用。

方法

采用逆转录-聚合酶链反应（RT-PCR）、原位杂交和免疫组织化学方法对培养的大鼠和人MC进行研究。

结果

MC中TNF及其受体mRNA的表达以及蛋白质合成均有体现。

结论

（1）MC是TNF的靶细胞，MC具有针对TNF的特异性细胞表面受体。（2）TNF通过自分泌和旁分泌机制作用于MC。

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