Dong B, Zou W Z, You J F
Department of Pathology, Beijing Medical University.
Zhonghua Bing Li Xue Za Zhi. 1994 Feb;23(1):10-3.
The role of glomerular mesangial cells (MC) and mesangial matrix (MM) in glomerular sclerosis was studied by using rat mesangial cell culture, immunohistochemical studies for laminin, laminin receptors as well as collagen types IV and III. The effect of tumor necrosis factor (TNF) and endothelin (ET) on MC was also studied. Results show that TNF and ET have potent mitogenic effects on MC. The glomerular MC possess the special capability of secreting TNF and ET. TNF and ET can also influence and induce the secretion of each other. The MM is increased in the MC nodular colonies formed after prolonged culture. These colonies are composed of collagen IV and collagen III. Therefore, injuring factors can cause MC and MM to proliferate and produce glomerulosclerosis.
通过大鼠系膜细胞培养、层粘连蛋白、层粘连蛋白受体以及IV型和III型胶原的免疫组织化学研究，探讨了肾小球系膜细胞（MC）和系膜基质（MM）在肾小球硬化中的作用。还研究了肿瘤坏死因子（TNF）和内皮素（ET）对MC的影响。结果表明，TNF和ET对MC有强大的促有丝分裂作用。肾小球MC具有分泌TNF和ET的特殊能力。TNF和ET也能相互影响并诱导彼此的分泌。长时间培养后形成的MC结节状集落中MM增加。这些集落由IV型胶原和III型胶原组成。因此，损伤因子可导致MC和MM增殖并产生肾小球硬化。
