Isolation and characterization of a new chromosome 8q24.1 band-specific microsatellite polymorphism.
作者信息
Xu L, Xia J, Tang Y, Pan Q, Huang L, Deng H
机构信息
National Laboratory of Medical Genetics, Hunan Medical University, Changsha.
出版信息
Hunan Yi Ke Da Xue Xue Bao. 1997;22(6):471-4.
PMID:10072981
Abstract
A clone, containing a 24-dinucleotide (CA)-repeat sequence, was isolated from chromosome 8q24.1 band-specific pUC19 library. It was localized to target chromosome using human-rodent hybrid cell panel. Eleven alleles were estimated from 56 unrelated individuals and the heterozygosity reaches 0.835. Linkage analysis of 11 Chinese pedigrees showed significant evidence for linkage of this new marker to three dinucleotide repeat markers at 8q23-24.1 region, with the most likely position of the marker between D8S85 and D8S199.
摘要
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