人类肿瘤坏死因子α（TNFAα）基因座处的一个高度多态性的CA重复序列标记。
A highly polymorphic CA repeat marker at the human tumor necrosis factor alpha (TNFA alpha) locus.
作者信息
Tsukamoto K, Ohta N, Shirai Y, Emi M
机构信息
Department of Molecular Biology, Nippon Medical School, Kawasaki, Japan.
出版信息
J Hum Genet. 1998;43(4):278-9. doi: 10.1007/s100380050090.
PMID:9852684
Abstract
Tumor necrosis factor alpha (TNF alpha) in activated monocytes exerts cytotoxic activity and has a variety of other biological effects. We isolated a polymorphic dinucleotide (CA) repeat sequence from a genomic clone containing the gene located at 6p21.3. High heterozygosity (0.80) makes this polymorphism a useful marker in the genetic study of disorders affecting immunological response and cell differentiation.
摘要
活化单核细胞中的肿瘤坏死因子α（TNFα）具有细胞毒性活性，并具有多种其他生物学效应。我们从一个基因组克隆中分离出一个多态性二核苷酸（CA）重复序列，该克隆包含位于6p21.3的基因。高杂合度（0.80）使这种多态性成为影响免疫反应和细胞分化的疾病遗传研究中的一个有用标记。
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