[结核性和隐球菌性脑膜炎脑脊液中的一氧化氮、肿瘤坏死因子-α和白细胞介素-8]
[Nitric oxide, TNF-alpha and IL-8 in cerebrospinal fluids of tuberculous and cryptococcic meningitis].
作者信息
Chen L, Jiang H, Wei C
机构信息
Department of Immunology and Microbiology, Hunan Medical University, Changsha.
出版信息
Hunan Yi Ke Da Xue Xue Bao. 1997;22(6):514-6.
The contents of NO, TNF-alpha and IL-8 in the cerebrospinal fluids (CSF) of patients with tuberculous and cryptococcic meningitis were detected. The results showed that the concentration of NO2-/NO3- and the levels of TNF-alpha and IL-8 in CSF of the two kinds of meningitis were higher than those of normal CSF, and the concentration of NO2-/NO3- correlated positively to the content of TNF-alpha. The results indicate that the over production of NO, TNF-alpha and IL-8 in CSF may involve in the tissue inflammation and damage of central nerve system infection.
检测了结核性脑膜炎和隐球菌性脑膜炎患者脑脊液（CSF）中一氧化氮（NO）、肿瘤坏死因子-α（TNF-α）和白细胞介素-8（IL-8）的含量。结果显示，两种脑膜炎患者脑脊液中NO2-/NO3-浓度以及TNF-α和IL-8水平均高于正常脑脊液，且NO2-/NO3-浓度与TNF-α含量呈正相关。结果表明，脑脊液中NO、TNF-α和IL-8的过度产生可能参与中枢神经系统感染的组织炎症和损伤。
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