Chen Y, Liu J, Yi C, Liu H
Laboratory of Pharmaceutics, Hunan Medical University, Changsha.
Hunan Yi Ke Da Xue Xue Bao. 1997;22(5):397-400.
Mice or rats were pretreated P. O. with 8.0 gg.kg-1, 15.0 g.kg-1 and 30.03 g.kg-1 of Jiangtang Oral Solution once daily for 10 days respectively. The results showed that Jiangtang Oral Solution did not affect the glycemia and lipid in normal mice and rats, but significantly lowered the blood sugar in hyperglycemic mice and rats induced by alloxan, adrenalin, and streptozotocin. Meanwhile, Jiangtang Oral Solution significantly lowered blood lipid in mice and rats induced by yolk and high cholesterol foods. This study provides a reliable pharmacologic base for the clincal use of Jiangtang Oral Solution.
将小鼠或大鼠分别以8.0 g·kg-1、15.0 g·kg-1和30.03 g·kg-1的剂量口服给予降糖口服液，每日1次，连续10天。结果表明，降糖口服液对正常小鼠和大鼠的血糖和血脂无影响，但能显著降低由四氧嘧啶、肾上腺素和链脲佐菌素诱导的高血糖小鼠和大鼠的血糖。同时，降糖口服液能显著降低由蛋黄和高胆固醇食物诱导的小鼠和大鼠的血脂。本研究为降糖口服液的临床应用提供了可靠的药理学依据。
