Slutsky A S
Department of Medicine, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
J Clin Pharmacol. 1999 Mar;39(3):246-51.
For a number of reasons, genetics has always been thought to be involved in asthma. It is only now, with several approaches and tools to make population genetic studies possible, that studies are intensified. Using both the candidate gene and the positional cloning approaches, there is evidence that predisposing factors, if not the disease itself, are genetically transferred. In addition, studies on inbred island populations have further demonstrated a high probability of a genetically transferable link. If the genes can be identified, diagnostic tests or predictions regarding the response to specific therapy are advances that would follow.
由于多种原因，遗传学一直被认为与哮喘有关。直到现在，随着多种使群体遗传学研究成为可能的方法和工具的出现，相关研究才得以加强。运用候选基因和定位克隆这两种方法，有证据表明，即便不是疾病本身，其易感因素也是可遗传的。此外，对与世隔绝的近亲群体的研究进一步证明了存在可遗传联系的高可能性。如果能够识别出这些基因，那么随之而来的进展将是针对特定疗法反应的诊断测试或预测。
