Levien M G, Bringelsen K A
Division of Pediatric Hematology/Oncology, The Cleveland Clinic Foundation, OH 44195, USA.
Semin Urol Oncol. 1999 Feb;17(1):40-5.
There has been substantial improvement in survival in patients with Wilms' tumor over the last 30 years in the United States. This has been the direct result of the efforts of the National Wilms' Tumor Study Group. This group was established in 1969 through the conglomeration of pediatric divisions of two existing cooperative study groups for the purpose of accruing large enough patient populations to conduct meaningful clinical trials. Thus far, four National Wilms' tumor trials have been completed. The fifth study is currently accepting patients for treatment. This article reviews the remarkable success in the treatment of Wilms' tumor and the evolution of present day postoperative therapy.
在过去30年里，美国肾母细胞瘤患者的生存率有了显著提高。这是国家肾母细胞瘤研究组努力的直接成果。该研究组于1969年通过合并两个现有合作研究组的儿科部门而成立，目的是积累足够多的患者群体以开展有意义的临床试验。迄今为止，已完成了四项国家肾母细胞瘤试验。第五项研究目前正在招募患者进行治疗。本文回顾了肾母细胞瘤治疗取得的显著成功以及当今术后治疗的演变。
