Stam R, Croiset G, Akkermans L M, Wiegant V M
Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, Utrecht University, The Netherlands.
Physiol Behav. 1999;65(4-5):679-84. doi: 10.1016/s0031-9384(98)00208-x.
Individual differences in behavioral and physiological response patterns to stress may contribute to vulnerability for stress-related illnesses such as functional gastrointestinal disorders. Animal models could give clues about specific individual determinants of intestinal reactivity to stress and stress-induced sensitization. Rats fitted with permanent electrodes on the proximal colon were exposed to a single session of foot shocks (10 x 6 s in 15 min, preshocked) or no shocks (control). Two weeks later, the preshocked group showed a significantly greater colonic spike burst response to a novel shock-prod stressor in the home cage than controls. The increase in burst frequency was positively correlated with the duration of active burying of the threatening prod in both experimental groups, but not with other behavioral components. Basal colonic burst frequency at rest was negatively correlated with the increase in burst frequency due to shock-prod stress in both groups, but the degree of sensitization in preshocked rats vs. controls was of similar magnitude in rats with low and high basal colonic burst frequency. The results indicate that colonic responsivity to stress is related to both basal motility status and individual coping strategies.
行为和生理应激反应模式的个体差异可能导致诸如功能性胃肠疾病等与应激相关疾病的易感性。动物模型可以提供有关肠道对应激和应激诱导敏化反应的特定个体决定因素的线索。在近端结肠植入永久性电极的大鼠接受单次足部电击（15分钟内10次×6秒，预电击）或不接受电击（对照）。两周后，预电击组对新的电击棒应激源在饲养笼中表现出比对照组明显更大的结肠尖峰爆发反应。在两个实验组中，爆发频率的增加与对威胁性电击棒进行主动掩埋的持续时间呈正相关，但与其他行为成分无关。两组静息时的基础结肠爆发频率与电击棒应激导致的爆发频率增加呈负相关，但在基础结肠爆发频率低和高的大鼠中，预电击大鼠与对照组相比的敏化程度相似。结果表明，结肠对应激的反应性与基础运动状态和个体应对策略均有关。
