Stam R, Croiset G, Akkermans L M, Wiegant V M
Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, Utrecht University, The Netherlands.
Behav Brain Res. 1997 Nov;88(2):231-8. doi: 10.1016/s0166-4328(97)00046-6.
There are indications that the severity of functional gastrointestinal disturbances in humans is linked to individual coping styles. In rodents, the open field test can be used to assess individual differences in behavioural responsivity to novel challenges. Two groups of Wistar rats were selected for high (HA) and low (LA) locomotor activity in a novel open field and fitted with electrodes on the proximal colon. During subsequent exposure to a novel box, a smaller locomotor activation in LA was accompanied by a greater increase in colonic spike burst activity compared to HA rats, even though this novel stressful challenge did not result in a clear defecation response in either group. In contrast, no marked behavioural differences between HA and LA were seen in the shock prod paradigm. Although detection of divergent behavioural responsivity in HA and LA rats may depend on stimulus quality or intensity, combined use of behavioural selection and intestinal motility recording in freely moving rats may offer a model to study individual vulnerability to stress-related disturbances of intestinal function.
有迹象表明，人类功能性胃肠功能紊乱的严重程度与个体应对方式有关。在啮齿动物中，旷场试验可用于评估对新挑战的行为反应性的个体差异。选择两组Wistar大鼠，分别在新的旷场中表现出高（HA）和低（LA）运动活性，并在近端结肠上安装电极。在随后暴露于一个新盒子的过程中，与HA大鼠相比，LA大鼠较小的运动激活伴随着结肠尖峰爆发活动的更大增加，尽管这种新的应激挑战在两组中均未导致明显的排便反应。相比之下，在电击刺激范式中，HA和LA之间未观察到明显的行为差异。尽管检测HA和LA大鼠中不同的行为反应性可能取决于刺激质量或强度，但在自由活动的大鼠中结合使用行为选择和肠道运动记录可能提供一个模型，以研究个体对与压力相关的肠道功能紊乱的易感性。
