一种小鼠γ疱疹病毒的免疫控制，独立于CD8 + T细胞。

Immunological control of a murine gammaherpesvirus independent of CD8+ T cells.

作者信息

Stevenson P G, Cardin R D, Christensen J P, Doherty P C

出版信息

J Gen Virol. 1999 Feb;80 ( Pt 2):477-483. doi: 10.1099/0022-1317-80-2-477.

Abstract

Adult thymectomized C57 BL/6J mice were depleted of T cell subsets by MAb treatment either prior to, or after, respiratory challenge with murine gammaherpesvirus-68. Protection against acute infection was maintained when either the CD4+ or the CD8+ T cell population was greatly diminished, whereas the concurrent removal of both T cell subsets proved invariably fatal. The same depletions had little effect on mice with established infection. The results indicate firstly that both CD4+ and CD8+ T cells play a significant part in dealing with the acute infection, and secondly that virus-specific antibody contributes to controlling persistent infection with this gammaherpesvirus.

摘要

成年去胸腺C57 BL/6J小鼠在受到鼠γ疱疹病毒-68呼吸道攻击之前或之后，通过单克隆抗体处理使T细胞亚群减少。当CD4⁺或CD8⁺T细胞群体大幅减少时，对急性感染的保护作用得以维持，而同时去除这两个T细胞亚群则总是致命的。相同的细胞减少对已建立感染的小鼠几乎没有影响。结果表明，首先，CD4⁺和CD8⁺T细胞在应对急性感染中都发挥着重要作用；其次，病毒特异性抗体有助于控制这种γ疱疹病毒的持续感染。