Opferman J T, Ober B T, Ashton-Rickardt P G
Committee on Immunology, Department of Pathology, Committee on Developmental Biology, The University of Chicago, Gwen Knapp Center for Lupus and Immunology Research, Chicago, IL 60637, USA.
Science. 1999 Mar 12;283(5408):1745-8. doi: 10.1126/science.283.5408.1745.
A central question in immunology is the origin of long-lived T cell memory that confers protection against recurrent infection. The differentiation of naïve T cell receptor transgenic CD8+ cells into effector cytotoxic T lymphocytes (CTLs) and memory CD8+ cells was studied. Memory CD8+ cells that were generated after strong antigenic stimulation were the progeny of cytotoxic effectors and retained antigen-specific cytolytic activity 10 weeks after adoptive transfer to antigen-free recipient mice. Thus, potential vaccines based on CTL memory will require the differentiation of naïve cells into post-effector memory T cells.
免疫学中的一个核心问题是赋予抵御反复感染能力的长寿T细胞记忆的起源。研究了初始T细胞受体转基因CD8+细胞向效应细胞毒性T淋巴细胞（CTL）和记忆性CD8+细胞的分化。在强烈抗原刺激后产生的记忆性CD8+细胞是细胞毒性效应细胞的后代，在过继转移至无抗原受体小鼠后10周仍保留抗原特异性溶细胞活性。因此，基于CTL记忆的潜在疫苗将需要初始细胞分化为效应后记忆T细胞。
