Lu Y, Tong Q, He L
Beijing University of Physical Education.
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 1997 Aug;13(3):198-201.
Androgen receptor (AR) binding and testosterone (T) level of skeletal muscle of rat at the different conditions were observed in this study. The exhausted exercise could up-regulate the AR binding of levator ani muscle, but decrease the T level in quadriceps. The long term exhausted exercise had no effect on the AR binding of quadriceps. The fitness exercise could up-regulate the AR binding of quadriceps but have no significant effect on the T level in quadriceps. There was no effect on the AR binding but T level was increased after injection of HCG for 4 days in quadriceps. The increase of T level in skeletal muscle after injection of HCG for 4 days was higher than that for 8 days. From these results it is suggested that the effect of exercise on the regulation of hormone on skeletal muscle may be in two directions. Both AR binding capacity and T level must be considered in skeletal muscle anabolism.
本研究观察了不同条件下大鼠骨骼肌的雄激素受体（AR）结合情况和睾酮（T）水平。力竭运动可上调提肛肌的AR结合，但降低股四头肌中的T水平。长期力竭运动对股四头肌的AR结合无影响。适应性运动可上调股四头肌的AR结合，但对股四头肌中的T水平无显著影响。注射人绒毛膜促性腺激素（HCG）4天后，对AR结合无影响，但股四头肌中的T水平升高。注射HCG 4天后骨骼肌中T水平的升高高于注射8天的情况。从这些结果表明，运动对骨骼肌激素调节的影响可能有两个方向。在骨骼肌合成代谢中必须同时考虑AR结合能力和T水平。
