Young C, Sandstedt P, Skoglund A
Department of Oral Pathology, School of Dentistry, Karolinska Institute, Huddinge, Sweden.
Int J Oral Maxillofac Implants. 1999 Jan-Feb;14(1):72-6.
The aim of this study was to investigate the possible use and ultimate fate of anorganic xenogenic bone for the restoration of defects in the maxillae and mandibles of adult rabbits. Furthermore, anorganic xenogenic bone was compared with implanted autogenous bone particles with regard to the response of the surrounding connective tissue and possible resorption of these implants by multinucleated cells. Results showed that after 12 weeks, the implanted autogenous bone was actively resorbed by multinucleated cells, and new bone was formed in close apposition to the particles. In contrast, implanted anorganic xenogenic bone was degraded to a much lesser extent, and new bone was seen adjacent to the anorganic bone particles without signs of resorption. Further long-term studies are needed to determine whether anorganic xenogenic bone may be regarded as a resorbable material and whether any side effects occur as a result of this material's tendency to linger on in the recipient bed.
本研究的目的是探讨无机异种骨用于修复成年兔上颌骨和下颌骨缺损的可能用途及最终转归。此外，就周围结缔组织的反应以及这些植入物被多核细胞的可能吸收情况而言，对无机异种骨与植入的自体骨颗粒进行了比较。结果显示，12周后，植入的自体骨被多核细胞积极吸收，并且在颗粒紧邻处形成了新骨。相比之下，植入的无机异种骨降解程度要小得多，在无机骨颗粒旁可见新骨，且无吸收迹象。需要进一步进行长期研究，以确定无机异种骨是否可被视为可吸收材料，以及由于该材料在受体床中持续存在的倾向是否会产生任何副作用。
