Schlegel Karl Andreas, Fichtner Gabriele, Schultze-Mosgau Stefan, Wiltfang Jörg
Department of Maxillofacial Surgery of Friedrich-Alexander-Universität Erlangen-Nuremberg, Erlangen, Germany.
Int J Oral Maxillofac Implants. 2003 Jan-Feb;18(1):53-8.
The aim of this study was to compare a bovine bone substitute (Bio-Oss) to autogenous bone with respect to its value as a material for sinus augmentation.
In 10 beagle dogs 12 months of age, the 3 maxillary premolars were extracted on both sides. Six weeks later, 2 cavities of predefined size were produced in the region of the nasal cavity. The antral window was 25 mm long and had a vertical extension of 7 mm. Two Frialit-2 implants (3 x 8 mm) were placed in each bone defect (n = 20). Every implant was primarily stable because of fixation in native bone. In each maxilla, 1 bone defect was filled with autogenous bone harvested from the mandible and 1 was filled with Bio-Oss (material selected at random). The animals were sacrificed at 90 and 180 days, and histologic specimens were examined and the results subjected to statistical analysis by the Wilcoxon test for paired observations.
No healing problems were observed. Histologically, after 90 days the volume of the augmentation showed a reduction of 14.6 +/- 4.4% within the Bio-Oss group and 3.8 +/- 2.5% in the group with autogenous bone. Bone-implant contact of 52.16 +/- 13.15% in the Bio-Oss group and 60.21 +/- 11.46% in the autogenous bone group was observed. At 180 days, the Bio-Oss group showed bony ingrowth of the substitute, whereas in the autogenous group a differentiation from original bone could no longer be made. The volume reduction was 16.5 +/- 8.67% in the Bio-Oss group and 39.8 +/- 16.14% in the autogenous group. Bone-implant contact of 63.43 +/- 19.56% in the Bio-Oss group and 42.22 +/- 12.80% in the autogenous bone group was measured.
The results indicated that because of the nonresorptive properties of the bone substitute Bio-Oss, regeneration of the defects is achievable. It was demonstrated that the bone substitute seemed to behave as a permanent implant. The volume of the area augmented by autogenous bone decreased over the observation period.
本研究旨在比较牛骨替代物（Bio-Oss）与自体骨作为鼻窦增高材料的价值。
选取10只12月龄的比格犬，双侧拔除3颗上颌前磨牙。6周后，在鼻腔区域制作2个预定大小的腔隙。鼻窦开窗长25mm，垂直延伸7mm。每个骨缺损处植入2枚Frialit-2种植体（3×8mm）（n = 20）。由于种植体固定于天然骨，每个种植体初始均稳定。在每侧上颌骨中，1个骨缺损用取自下颌骨的自体骨填充，另1个用Bio-Oss填充（随机选择材料）。在90天和180天时处死动物，检查组织学标本，并通过配对观察的Wilcoxon检验对结果进行统计分析。
未观察到愈合问题。组织学检查显示，90天时，Bio-Oss组增高体积减少14.6±4.4%，自体骨组减少3.8±2.5%。Bio-Oss组骨-种植体接触率为52.16±13.15%，自体骨组为60.21±11.46%。180天时，Bio-Oss组显示替代物有骨长入，而自体骨组已无法区分原始骨。Bio-Oss组体积减少16.5±8.67%，自体骨组减少39.8±16.14%。Bio-Oss组骨-种植体接触率为63.43±19.56%，自体骨组为42.22±12.80%。
结果表明，由于骨替代物Bio-Oss的不可吸收特性，缺损再生是可行的。已证明骨替代物似乎表现为永久性植入物。在观察期内，自体骨增高区域的体积减小。
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