Bøhmer T, Røseth A
Medisinsk klinikk, Aker sykehus, Oslo.
Tidsskr Nor Laegeforen. 1999 Jan 30;119(3):369-70.
Digitoxin is frequently used in Norway in the treatment of cardiac failure. Digitalis glycosides may give rise to a number of side effects difficult to separate from disease in the elderly. Six patients aged 77-93 years, treated with digitoxin 0.05 mg/day, were hospitalized due to digitalis intoxication. Mean digitoxin half-life was 25.2 days. This is significantly more than reported in other studies on younger patients. The symptoms of digitoxin intoxication disappeared on discontinuation of medication. The slow elimination of digitoxin may be related to reduced serum albumin concentration. When digitoxin is used in the treatment of heart failure in the very elderly patients, one should be aware of the possibility of digitoxin intoxication, even at a low dose.
洋地黄毒苷在挪威常用于治疗心力衰竭。洋地黄糖苷可能会引发一些副作用，这些副作用在老年人中很难与疾病本身区分开来。6名年龄在77至93岁之间、每天服用0.05毫克洋地黄毒苷的患者因洋地黄中毒而住院。洋地黄毒苷的平均半衰期为25.2天。这明显高于其他针对年轻患者的研究报告。停用药物后，洋地黄毒苷中毒的症状消失了。洋地黄毒苷消除缓慢可能与血清白蛋白浓度降低有关。当在高龄患者中使用洋地黄毒苷治疗心力衰竭时，即使是低剂量，也应意识到洋地黄毒苷中毒的可能性。
